Third, obesity‐related factors, such as insulin and leptin, induce AKT‐mediated phosphorylation of ACLY at Ser455 to promote the nuclear translocation of ACLY, which increases histone acetylation levels and upregulates the pyrimidine metabolism gene DHODH and ultimately promotes tumors [91]. This evidence concerns the gene ACLY and obesity due to melanocortin 4 receptor deficiency.