PKM and liver cancer: PKM2 is also a target of many long noncoding RNA (lncRNA); for example, the lncRNA highly upregulated in liver cancer (HULC) significantly increases PKM2 expression in hepatocellular carcinoma (HCC) by enhancing cyclin D1 through the autophagy‐miR675‐PKM2 signaling pathway, supporting the oncogenic role of HULC in HCC stem cells [26].