The PI3K/AKT/mTORC1‐HIF1α axis additionally promotes glucose metabolic reprogramming, leading to the overexpression of GLUT1, thereby suggesting that both GLUT1 and mutant IDH1 could serve as potential targets for various cancers, including colorectal cancer and glioblastoma [129, 130, 131]. The gene discussed is AKT1; the disease is cancer.