FOXO1 and neoplasm: The PI3K/AKT signaling pathway is a pivotal axis for multiple upstream signaling in tumor cells, aggregating and regulating many downstream transcriptional targets, including mTOR (regulates HIF‐1α and c‐Myc on downstream), Forkhead box protein O1 (FoxO1), GSK3, and other key molecules [44, 45].