Energy stress or glucose deficiency in the TME activates adenosine monophosphate‐activated protein kinase (AMPK), which activates CREB1 (a proto‐oncogene) to induce GLUT3 expression in colorectal cancer cells by anchoring the CREB1 binding site on the SLC2A3 promoter. Here, SLC2A3 is linked to colorectal cancer.