Under hypoglycemic conditions, GLUD plays a crucial role in promoting tumor growth by catalytically generating α‐KG that directly induces the Inhibitor of nuclear factor kappa‐B kinase subunit beta (IKKβ) and NF‐κB signaling, upregulates GLUT1 expression to alleviate glucose deficiency, and facilitates tumor cell proliferation. Here, NFKB1 is linked to neoplasm.