As the most important cancer‐promoting molecule Myc, chromosome immunoprecipitation‐sequencing (ChIP‐seq) analysis yielded over 400 nuclear‐encoded mitochondrial genes, including genes associated with OXPHOS complexes, mitochondrial transcription/translation factors, mitochondrial ribosomes, and other transcription factors involved in mitochondrial biogenesis, which were identified as Myc targets. The gene discussed is MYC; the disease is cancer.