PPARGC1A and Familial prostate cancer: PGC1α is a key transcriptional regulator of mitochondrial OXPHOS that can promote tumor progression and metastasis; its overexpression in prostate cancer cell lines with undetectable PGC1α induces OXPHOS, thereby reversing the Warburg effect; and the oncogenic or tumor suppressor effects of PGC1α, as well as the induction of OXPHOS, are highly situation‐dependent [176].