The high‐dosage of EPO suppressed macrophage M1 polarization with reduced iNOS expression and alleviated systemic inflammation, showing the protective effects on SA‐AKI patients,43 whereas side‐effects were also induced, such as hypertension and thrombosis, but could be avoided by using HBSP, only binds to EPOR/βcR.44 This evidence concerns the gene EPOR and hypertensive disorder.