C3 and age-related macular degeneration: Complete FI deficiency has been associated with a consumptive C3 deficiency and recurrent infections with encapsulated microorganisms [23] or aseptic cerebral inflammation [48, 49] while heterozygous mutations in CFI have been liked to immunopathology in the form of atypical haemolytic uraemic syndrome [50, 51] and AMD [7, 8].