Shikonin functions mainly through RIPK1 in the PANC-1 cell line and has no obvious effect on RIPK3; however, in AsPC-1 cells, it targets RIPK3 to induce cell necroptosis (Chen et al., 2017), and in nasopharyngeal carcinoma, shikonin upregulates both RIPK1 and RIPK3 expression and MLKL expression to promote necroptosis (Liu et al., 2019). The gene discussed is RIPK3; the disease is nasopharyngeal carcinoma.