In addition, Xiang et al. reported that Paris saponin VII directly interacts with the MST2-MOB1-LATS1 complex, increasing their interaction, thereby promoting the MOB1-mediated phosphorylation of LATS1 and LATS1-mediated phosphorylation and degradation of YAP, and that the inhibition of YAP ultimately activates the Hippo pathway and autophagy in breast cancer cells (Xiang et al., 2022). Here, LATS1 is linked to breast cancer.