Gambogic acid derived from Garcinia hanburyi trees promotes gastric cancer cell death through necroptosis; regarding the mechanism of action, gambogic acid increases the p-RIPK1/RIPK1, p-RIPK3/RIPK3, and p-MLKL/MLKL ratios; enhances necrosome complex formation; activates the downstream effector proteins phosphoglycerate mutase family member 5 (PGAM5) and Drp-1 (Chen et al., 2024). Here, PGAM5 is linked to gastric cancer.