β-Elemene also reverses resistance to gefitinib in GBM through the inactivation of the EGFR/AKT signaling pathway and activation of autophagy and enhances the anticancer effect of 5-fluorouracil in CRC by triggering autophagy; however, the detailed mechanism remains unknown (Mu et al., 2016; Zhang et al., 2020d). Here, AKT1 is linked to colorectal carcinoma.