TP53 and gastric cancer: In gastric cancer, molecular docking revealed lysine-specific demethylase 4D (KDM4D) as the target of tanshinone I; this interaction reduces the protein level of KDM4D, which directly binds to p53 and suppresses its transcriptional activation of the downstream gene SLC7A11, ultimately leading to ferroptosis (Xia et al., 2023).