Interestingly, tanshinol A induces necroptosis via MLKL but not through RIPK1 or RIPK3 in lung cancer; it causes the massive production of ROS, increases the phosphorylation level of MLKL and promotes MLKL transfer to the plasma membrane to execute necroptosis (Liu X. et al., 2020). This evidence concerns the gene MLKL and lung cancer.