PFKFB4 and melanoma: A β-Elemene isopropanolamine derivative reduces the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), a key enzyme in glycolysis, thus inhibiting glycolysis and triggering autophagy in melanoma cells (Jalal et al., 2022).