Up-regulation of E-cadherin expression was observed in the neoplasm from the xenograft tumor model using immunohistochemistry staining, which is consistent with the negative correlation between the mRNA levels of T132E and CDH1 revealed from gene expression analysis of the Breast Invasive Carcinoma dataset from TCGA and PanCancer (Fig. S3H, I). This evidence concerns the gene CDH1 and neoplasm.