HMGB1 and neoplasm: In the course of the ICD process, tumor cells release a variety of damage-associated molecular patterns (DAMP) molecules, such as adenosine triphosphate (ATP), calreticulin (CRT), and high mobility group box 1 (HMGB1), which have the capacity to facilitate the maturation of dendritic cells (DCs) and initiate sustained anti-tumor immune responses [19].