INS and prediabetes syndrome: In another study that recruited men with prediabetes between the ages of 35 and 70 years (mean age: 56 ± 9 years) (5), participants who adhered to an early TRE regimen (i.e. with the eating window early in the day) without weight loss displayed decreased fasting and post-prandial insulin levels, increased insulin sensitivity, and decreased lipid oxidative stress (measured by 8-isoprostane levels).