IL-16 plays different roles in various pathological processes; it acts as a chemoattractant in some diseases, a pro-inflammatory factor in others, and may even function as an inhibitor in Th2-mediated diseases (Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia, and Th2-type cytokine production in mice) (45). Here, IL16 is linked to Increased total eosinophil count.