Microvesicles or ectosomes arise from multiple biogenesis pathways, such as releasing large oncosomes from bladder cancer cells, forming smaller “classical” ectosomes on the surface of colorectal cancer cells, secreting more smaller ectosomes including ARMMs (ARRDC1-mediated microvesicles) through arrestin domain-containing protein 1 (ARRDC1)-dependent pathway, and budding off from the tip or side of the protruding surface. Here, ARRDC1 is linked to colorectal cancer.