We initially compared the gene set expression between male and female WT mice, finding a significant reduction, albeit below a fold change of 2.5, in the expression levels of two genes in males compared to females - Fos (FBJ osteosarcoma oncogene) and Adcy8 (Adenylate cyclase 8) (Fig. 6C). The gene discussed is FOS; the disease is osteosarcoma.