BRB dysfunction is relevant to PD progression as the sleepdisorders and depression cause sleep disturbances and autonomic dysfunctionin early and prodromal PD.17 The aggregationsof α–α-synuclein and degeneration of dopaminergicneuron, leading to motor and nonmotor symptoms, including sleep disorders,are major side effects of PD,18 which causedisturbances in BRB. The gene discussed is SNCA; the disease is Parkinson disease.