GBA1 and Rett syndrome: Mitochondrialalterations have also been observed in Rett syndrome (RTT), a neurodevelopmentaldisorder, and the absence of the MECP2 gene in RTT may lead to alteredmitochondrial function and elevated levels of cellular oxidative stress.60 Additionally, mutations in the glucocerebrosidase(GBA) gene, which is associated with PD, can also contribute to mitochondrialdysfunction and altered lipid homeostasis.