In humans TDP-43 is involved in neurodegenerative pathologies amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD)(Neumann et al., 2006), and in degenerative myopathies sporadic inclusion bodies myositis (sIBM)(Cortese et al., 2014)and myoclonic epilepsy associated with ragged-red fibers (MERRF)(Mancuso et al., 2004; Mori et al., 2019). Here, TARDBP is linked to amyotrophic lateral sclerosis.