TARDBP and amyotrophic lateral sclerosis: Interestingly, this fibrillation site coincides with the amino terminal region of TDP-43 proteolytic fragment CTF 219-414 whichin vivoforms intracellular insoluble aggregates and is found also in extracellular vesicles isolated from plasma of ALS patients(Zhang et al., 2007; Nonaka et al., 2009; Casarotto et al., 2022).