Notably, TDP-43 regulates splicing of proteins important for cholesterol biosynthesis(Egawa et al., 2022)and cholesterol metabolism is altered in ALS patients(Abdel-Khalik et al., 2017), whilst phosphatidylcholine has neuroregenerative effects on cultured neural stem cells under inflammatory stress(Magaquian et al., 2021). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.