A study found that a Ki-67 index greater than 45% is defined as aggressive lymphoma, with a sensitivity of 85% and a specificity of 88.8%. Rebiere et al. conducted a study of Ki-67 expression in DLBCL, and the results showed that the median Ki-67 positivity was 80% [65]. Here, MKI67 is linked to diffuse large B-cell lymphoma.