BCL6 and diffuse large B-cell lymphoma: The BCL-2 protein plays a crucial role in the development of NHL [31]. The translocation t(14;18), where BCL-2 is located on chromosome 18 and the heavy Ig chain is on chromosome 14, leads to overexpression of the BCL-2 protein, which occurs in approximately 35% of DLBCL cases [32] While the BCL-6 gene has genetic alterations in approximately 20% to 40% of individuals [33].