Recent research has identified multiple nuclear proteins such as squamous cell carcinoma antigen (SCCA/SerpinB3), high mobility group box chromosomal protein 1 (HMGB1), carcinoembryonic antigen (CEA), and cytokeratin fragment antigen 21-1 (CYFRA 21-1), control the different signal transduction pathways entailed directly or indirectly in growth regulation mechanisms of disease tissues, tumor development, and cervical carcinogenesis [9-12]. This evidence concerns the gene HMGB1 and neoplasm.