Only six (32%) patients were previously healthy, and 13 (68%) had a pre-existent medical condition: cardiac heart disease (congenital heart disease (n=5) and rheumatic valvopathy (n=2)), familiar hypercholesterolemia (n=1), SCD (n=1), NF-1 (n=1), medulloblastoma (n=1), hemolytic uremic syndrome (n=1), chromossomopathy (duplication of the Xq27.3-q28 region) (n=1), and migraine with aura (n=2). This evidence concerns the gene NF1 and Schnyder corneal dystrophy.