Shao et al. further used the dual luciferase reporter gene system to prove that SETDB1 is the direct target gene of miR-621, and that miR-621 can activate p53 signaling pathway by inhibiting SETDB1, and ultimately enhance the radiosensitivity of HCC cells (Shao et al., 2019). Here, TP53 is linked to hepatocellular carcinoma.