The study found that while mucosal SETDB1 expression was not impaired in the vast majority of inflammatory bowel disease (IBD) patients, a comparison of IBD and non-IBD exome revealed overexpression of rare missense variants of SETDB1 in IBD individuals, some of which are predicted to be associated with loss of function and may be associated with the pathogenesis of intestinal inflammation (Juznić et al., 2021). Here, SETDB1 is linked to inflammatory bowel disease.