Moreover, in NSCLC, SETDB1 activates K63-linked AKT ubiquitination by trimethylating AKT at K64 and subsequently by recruiting Jumonji domain protein 2A (JMJD2A) and E3 ligase TRAF6 to the AKT complex (Piracha et al., 2024). This evidence concerns the gene SETDB1 and non-small cell lung carcinoma.