At the same time, as a genome-wide chromatin modifier, SETDB1 also has many other physiological functions, including regulating PML-NB(Promyelocytic leukaemia nuclear bodies) complex formation (Cho et al., 2013), mediating X chromosome inactivation (Minkovsky et al., 2014), inhibiting endogenous retrovirus (Matsui et al., 2010), regulating cell proliferation (Chen et al., 2017), regulating inflammatory response (Juznić et al., 2021), and regulating helper T cell differentiation (Hu et al., 2021). This evidence concerns the gene PML and acute promyelocytic leukemia.