SETDB1 and non-small cell lung carcinoma: It has been reported that the high expression of SETDB1 is associated with the advanced pathological status of patients with NSCLC (Inoue et al., 2015), but other studies have found that SETDB1 is strongly expressed in the early stage of NSCLC (Wu et al., 2014; Lafuente-Sanchis et al., 2016).