More recently, ITGA6 clinical cases have been reported to also cause the same intestinal and skin phenotype.4, 5, 6, 7, 8, 9, 10, 11, 12, 13The epidermolysis bullosa in these cases is frequently lethal in neonates and infants, due to severe mucocutaneous fragility and aplasia cutis congenita.3 The gene discussed is ITGA6; the disease is epidermolysis bullosa.