This region is formed by a thin layer of epithelium, only 2 or 3 cell layers thick, residing between the nail bed and the underlying connective tissue.14While nail dystrophy can be associated with JT-EB, our review of all previously reported ITGA6 cases (Table 1) did not find any report of either subungual hemorrhage or onycholysis. This evidence concerns the gene ITGA6 and epidermolysis bullosa.