FGFR2 and intrahepatic cholangiocarcinoma: Literature reports indicate that chromosomal rearrangements contribute to around 50% of FGFR2 fusions in intrahepatic cholangiocarcinoma (iCCA), with the possibility of false negatives in FISH analysis.45Furthermore, due to its low throughput and limited ability to detect only one target at a time, FISH analysis is time-consuming for the detection of multiple genes, such as FGFR1–4.