S100A9 and acute myeloid leukemia: The S100A8 and S100A9 genes, on the other hand, are mainly involved in the process of immune response, and they can regulate the function of T and B cells in the bone marrow microenvironment of AML patients, affecting the production of antibodies and the process of antigen presentation (Mondet, Chevalier & Mossuz, 2021).