For example, major histocompatibility antigen (MHC) class I and II molecules on the surface of tumor cells have been identified in a variety of human cancers, especially recurrent AML, by mediating T cell recognition and killing of tumor cells, suggesting that AML cells can evade the body’s immune surveillance by decreasing their immunogenicity (Del Campo et al., 2012; Stolzel et al., 2012). The gene discussed is HLA-C; the disease is acute myeloid leukemia.