Binding of the NKG2D receptor on the surface of this cell line to the MICA/B ligand on the surface of AML cells promotes NK cell activation and AML cell killing, thus indirectly affecting the drug sensitivity of AML cell lines (Xing & Ferrari de Andrade, 2020; Baragano Raneros et al., 2015). The gene discussed is MICA; the disease is acute myeloid leukemia.