The wound healing assay revealed that the wound closure rate of HAP1 cells with si-S100A8 silencing was significant reduced (p < 0.05, Figs. 9B, 9C) and the cell numbers of HAP1 cells with si-S100A8 silencing in the trans-well assay was also significantly decreased (p < 0.05, Figs. 9D, 9E), indicating the S100A8 may be involved in the leukemia migration and invasion. This evidence concerns the gene S100A8 and leukemia.