By employing linear regression analysis with DLL4 and VE-cadherin content as the dependent variables, and considering predictive variables such as sex, age, BMI, presence of T2DM, Systolic pressure, radial artery diameter, and head artery diameter, the findings indicated a highly significant positive correlation between DLL4 expression levels and VE-cadherin expression levels (P < 0.001) (Table 3). This evidence concerns the gene DLL4 and type 2 diabetes mellitus.