PRKDC and neurodegenerative disease: For example, deficiency of DNA-PKcs has been shown to alleviate TH2-mediated airway inflammation in allergic asthma (Mishra et al., 2015) and DNA-PKcs induces cytochrome c release and mitochondrial apoptosis by upregulating Bax in neurodegenerative diseases (Liu, Naegele & Lin, 2009).