H2AX and acute lymphoblastic leukemia: However, a study showed that co-treatment with NU7441 and doxorubicin promoted the apoptosis of B-cell precursor acute lymphoblastic leukemia cells, leading to a decrease in DNA damage repair measured via γ-H2AX focus formation, which resulted in the loss of AIM2 inflammasomes in melanoma lesions and limited the activation of DNA-PKcs.