TNF and COVID-19: These expanded gene families are involved in signaling pathways related to “transcription and replication of influenza virus RNA,” “COVID‐19‐related pathways,” and “positive regulation of protein phosphorylation.” Notable contractions were observed in the “type I interferon” and “antibody‐related gene families.” Bibliometric analysis further underscored the several significance of critical immune genes, such as HSP90, Type I interferon, Type III interferon, and TNF.