FRMD5 and Nystagmus: It is also highly interesting that heterozygous mutations in FRMD5 were recently linked to a novel neurodevelopmental disorder with abnormal eye movements.38 Lu et al. reported eight individuals with missense variants in FRMD5 (summarized in Table S1), six of which had abnormal eye movements, described as an unspecified type of nystagmus and/or opsoclonus.