MT-ND4 and Leber hereditary optic neuropathy: Of note, rAAV2-ND4 comes in several forms; lenadogene nolparvovec (Lumevoq, GenSight Biologics), is a recombinant adeno-associated virus 2 of serotype 2 (rAAV2/2) vector encoding the human wild-type ND4 gene (rAAV2/2-ND4) as well as the rAAV2-ND4 from the Huazhong University of Science and Technology (China).16–21 This meta-analysis aims to compare the visual outcomes between treated and nontreated eyes with rAAV2-ND4 intravitreal injection in the treatment of LHON.