Notably, mice with a whole-body deletion of sensory neurons expressing the transient receptor potential-v1 (TRPV1) ion channel exhibit lower core body temperature and reduced energy, while those lacking the calcitonin gene-related peptide (CGRP) exhibited an increase in basal metabolic rate and showed resistance to diet-induced obesity, indicating a potential role for these neurons in energy homeostasis (Walker et al., 2010; Garami et al., 2011; Makwana et al., 2021). Here, TRPV1 is linked to obesity due to melanocortin 4 receptor deficiency.