From the insights of single-cell sequencing, the expressions of PPP2R5C, PPP2R5E, YWHAG, and CREBBP on TANs were significantly related to the metastatic of osteosarcoma, and these genes may play their roles via HIF-1, PI3K-AKT, and JAK-STAT signaling pathways (101). Here, PPP2R5C is linked to osteosarcoma.