The combined increase in the percentage of Foxp3+CD25+CD4+ Tregs and the equilibrium between proinflammatory IFN-γ, MIP-2, TNF-α, and anti-inflammatory IL-10 levels contributed to the therapeutic benefits of MSCs in ALI mice exposed to endotoxin-induced damage (171, 223). This evidence concerns the gene FOXP3 and acute respiratory distress syndrome.