NFKB1 and neoplasm: Additionally, several classical tumor-related pathways, such as “TNFα signaling via NFκB”, “oxidative phosphorylation”, “IL6 JAK STAT3 signaling”, “P53 pathway” and “KRAS signaling up”, showed higher activity in G2 in both cohorts (Figures 4E, F; Supplementary Tables S18, S19).