(59) suggested that up-regulated genes after panobinostat treatment were associated with type I IFN and IFN gamma (IFNγ) responses, p53 pathway, and cytokine signaling, including IL6 and TNFα in AML, which were consistent with our GSEA result (Figures 4E, F; Supplementary Tables S18, S19). Here, TP53 is linked to acute myeloid leukemia.