CD274 and cancer: For immunotherapy, an optimal AI-based predictive model should incorporate all pertinent clinical data about the patient, such as genetics, imaging, proteomics, pathological tissue, demographic data, medical history, etc. To allow the sharing of huge data from many locations, it is vital to enhance the integrity and objectivity of data gathering since ideas such as pan-cancer analysis have been reflected in the assessment of PD-1/PD-L1 efficacy (207).