Saha et al. revealed that in mice receiving PD-L1 −/− donor cells, reduction in inflammatory cytokine production, increase in apoptosis, and decline in aGVHD mortality without affecting graft-versus-leukemia response were observed, suggesting that interference with the PD-L1 pathway could serve as a potential therapeutic strategy to control or improve aGVHD (Saha et al., 2016; Schuchmann et al., 2008). Here, CD274 is linked to leukemia.