The network pharmacology analysis indicated that there were 47 potential targets of luteolin in treating NSCLC such as TP53, AKT1, EGFR, CASP3, TNF, JUN, VEGFA, MMP1, MMP9, HMOX1, MDM2, PIK3CG, BCL2L1, etc. We then constructed a PPI network to investigate the interactions among these targets. This evidence concerns the gene MMP1 and non-small cell lung carcinoma.