The network pharmacology analysis indicated that there were 47 potential targets of luteolin in treating NSCLC such as TP53, AKT1, EGFR, CASP3, TNF, JUN, VEGFA, MMP1, MMP9, HMOX1, MDM2, PIK3CG, BCL2L1, etc. We then constructed a PPI network to investigate the interactions among these targets. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.