In a trial of adult patients with advanced NSCLC that used blood liquid biopsies to assess circulating tumor DNA to determine whether patients with ROS1-positive NSCLC were treated with the entrectinib, the assay resulted in an 81% objective response rate to entrectinib, which is consistent with the results of a previous study using a tissue-based assay to identify ROS1 fusions (206). Here, ROS1 is linked to neoplasm.