Incorporation of the β‐diketone moiety of curcumin resulted in compounds represented by derivative Z‐CM‐I‐1 (16, Figure 3) which showed neuroprotection in a cellular AD model (MC65 cells that conditionally overexpress the 99‐residue carboxyl‐terminal [C99] fragment of the amyloid precursor protein) [221]. Here, APP is linked to Alzheimer disease.