To further determine whether CK1ε functions as a critical downstream effector of PRRC2A in the context of CRC progression, we overexpressed CSNK1E in PRRC2A‐knockdown colon cancer cells and found that knockdown of PRRC2A suppressed cell proliferation and migration, while CSNK1E overexpression rescued the suppressive effects (Figure 6A–C). The gene discussed is CSNK1E; the disease is colorectal carcinoma.