The core effectors YAP/TAZ translocate from the cytoplasm into the nucleus once the phosphorylation of YAP1 is removed.[20, 21] Similar to the WNT pathway, YAP1 upregulation was noticed in over 80% of human CRC cases.[22] In fact, although canonical WNT and YAP pathways seem to regulate distinct aspects of tissue development at different stages, emerging evidence has found them highly intertwined. Here, YAP1 is linked to colorectal carcinoma.