CSNK1E and colorectal carcinoma: Among these genes, CSNK1E was selected for further validation (Figure 5A), as it has been reported that CK1ε (encoded by CSNK1E) is a serine/threonine protein kinase that can activate WNT signaling[37] and concomitantly modulate YAP1 activity.[38] Analysis of TCGA data showed that CSNK1E is markedly upregulated in CRC at different stages (Figure S6A, Supporting Information).