PRRC2A and colorectal carcinoma: Increasing evidence indicated that m6A modification plays a critical role in CRC progression.[4, 8, 27, 28, 29] PRRC2A was recently identified as a novel m6A reader, and regulated oligodendroglial specification in brain development.[9] To understand the roles of PRRC2A in CRC, we first analyzed transcriptome data from The Cancer Genome Atlas (TCGA) database and found the mRNA level of PRRC2A markedly elevated in human CRC tumors compared to normal tissues (Figure S1A, Supporting Information).