LATS1 and colorectal carcinoma: However, this finding was contradictory to a previous report indicating that CK1δ/ɛ function as negative regulators of YAP1 activity, as phosphorylation of YAP1 at S381 can prime it for phosphorylation by CK1δ/ɛ to activate a phosphodegron, eventually leading to YAP1 degradation, in NIH‐3T3 cells.[38] This phenomenon could be due to marked downregulation of the key YAP1 regulators Lats1/2, which are responsible for priming YAP1 by phosphorylating it at S381, in CRC[58] and also indicates that CK1ε could have contrasting effects on YAP1 activity depending on the gene network context.