Apart from the carcinogen‐induced, colitis‐associated AOM‐DSS model, a mutant of Apc gene, a WNT pathway inhibitor, is another commonly used method to recapitulate familial CRC.[32] Consistently, the pro‐oncogenic effects of Prrc2a were confirmed when Prrc2a was deleted in Vil‐Cre;Apcfl/+ mice (Figure 1Q–T). Here, VIL1 is linked to colitis.