ATF1 transcriptionally upregulates the expression of PRRC2A, and elevated PRRC2A directly increases the stability of CSNK1E mRNA (encoding CK1ε) in an m6A‐dependent manner, whereas CK1ε concomitantly activates both WNT and YAP signaling pathways, thus promoting CRC progression. Here, CSNK1E is linked to colorectal carcinoma.