To further elucidate the in vivo functions of Prrc2a during tumor development, we generated Villin‐Cre‐driven conditional Prrc2a knockout (cKO) mice (Figure S2A, Supporting Information), in which Prrc2a was specifically deleted in the intestinal epithelium (Figure S2B, Supporting Information).[31] Under physiological conditions, Prrc2a is primarily expressed in the intestinal epithelium and in the lamina propria of the ileum and colorectum, while it is rare in the duodenum and jejunum (Figure S2C,D, Supporting Information). This evidence concerns the gene PRRC2A and neoplasm.