Moreover, the regulatory effects of PRRC2A on YAP1 activity were confirmed in APKS organoids (Figure S5H–J, Supporting Information).[36] Furthermore, analysis of human CRC tissues from TCGA data showed positive correlations between PRRC2A and YAP1, as well as between PRRC2A and YAP1's transcriptional coactivators TEAD1 and TEAD3 (Figure S5K–M, Supporting Information). This evidence concerns the gene YAP1 and colorectal carcinoma.