Also, IGF-1 (HR = 1.00; 95% CI = 1.00–1.01, P < 0.001) and gamma glutamyl transferase (HR = 0.99; 95% CI = 0.99–1.00, P < 0.001) remained highly correlated with incident BPH after controlling for all potential confounders. This evidence concerns the gene IGF1 and benign prostatic hyperplasia.