EGFR and lung adenocarcinoma: Yao et al. reported an SUVmax of 5 to predict bone metastasis, and that SUVmax could be a valuable noninvasive predictor of EGFR mutations in lung adenocarcinoma [27, 28].Our study showed that SUVmax > 6.3 indicates that the bone lesion is malignant, which is higher than that reported in the literature, and can be attributed to a minority of extreme values [29].