The most common TRAEs were anemia (91.7%), hypoproteinemia (77.8%), elevated aspartate aminotransferase (69.4%), elevated alanine transaminase (66.7%), hypothyroidism (58.3%), leukopenia (52.8%), diarrhea (51.4%), neutropenia (51.4%), hyponatremia (44.4%), and anorexia (43.1%). This evidence concerns the gene GPT and Hyponatremia.