In support of this concept, we could further show that platelets tether to the vessel wall via binding of the platelet receptor glycoprotein (GP) Ib to von Willebrand factor [57], and then become activated by GPVI/collagen and/or GPVI/fibrin(ogen) interactions during cerebral ischemia in a rodent model under MCAO already before recanalization (Fig. 1A) [8]. The gene discussed is GP6; the disease is brain ischemia.