The function of the RHBDF1 protein appears to be multifaceted, including facilitation of TGFα secretion and thus mediating G-protein coupled receptor (GPCR) ligand-activated transactivation of epidermal growth factor receptor (EGFR) [5, 6], protection of oxygen-independent degradation of hypoxia-inducible factor-1α (HIF-1α) [3], and promotion of endothelial-mesenchymal transition by activating the JNK/AP-1 signaling pathway, giving rise to destabilization of blood vessels, intensified hypoxic and inflammatory conditions, and augmented fibrotic stroma formation in breast cancer [7]. Here, EGFR is linked to breast cancer.