There was a significant association between serum NfL levels as a continuous covariate and CKD in Model 1 (OR 2.16; 95% CI 1.81- 2.59; p < 0.0001), Model 2 (OR 1.98; 95% CI 1.60-2.46; p < 0.001), and Model 3 (OR 1.60; 95% CI 1.40-1.82; p < 0.0001). Here, NEFL is linked to chronic kidney disease.