A new research has found that targeting domains 1 and 4/5 of β2GP1 was one of the most specific targets for APS, which was helpful for the diagnosis of APS.42 43 A retrospective analysis showed that transiently high or low titers of anti-β2GP1 had good predictive value for thrombosis in patients with SLE.44 The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.