This part of the research elucidated the regulatory mechanism of circSpna2 on key proteins involved in copper homeostasis and synaptic integrity, and highlighted the importance of the circSpna2/Keap1/Nrf2/Atp7b axis in mitigating the effects of cuproptosis and maintaining synaptic function, potentially offering new therapeutic strategies for TBI‐induced mood disorders. Here, KEAP1 is linked to mood disorder.