MAPT and supranuclear palsy, progressive, 1: Alternative models, such as seed-based approaches [4], the use of tau fibrils from PSP patients [14, 43], or AAV-mediated tau aggregation [50], can be used to address this discrepancy, because they provide a more accurate representation by inducing tau pathology in both neurons and glial cells, thereby better replicating the complexity of PSP [36].