Studies have found that WTAP can regulate the expression of mRNA that activates transcription factor 4 (AFT4) to promote the endoplasmic reticulum stress response and apoptosis, thereby promoting myocardial ischemia/reperfusion injury, while knocking down the expression of WTAP can inhibit endoplasmic reticulum stress and myocardial ischemia/reperfusion injury in cardiomyocytes (AC16) [29]. This evidence concerns the gene TCF4 and myocardial ischemia.