Using an RF model, SVM model and nomogram, the study identified 11 m6A methylation regulators (LRPPRC, YTHDC1, YTHDF1, HNRNPA2B1, WTAP, CBLL1, RBM15, HNRNPC, YTHDF2, RNMX and FTO) that could predict the occurrence of COPD effectively. Here, CBLL1 is linked to chronic obstructive pulmonary disease.