Differential analysis of 23 m6A methylation regulators highlighted that several, including METTL3, RBM15, RNM15B, CBLL1, YTHDC2, YTHDF1, YTHDF2, HNNRPC, LPPPRC, RBMX, FTO and ALKBH5, were significantly overexpressed in COPD patients. This evidence concerns the gene YTHDF1 and chronic obstructive pulmonary disease.