Differential analysis of 23 m6A methylation regulators highlighted that several, including METTL3, RBM15, RNM15B, CBLL1, YTHDC2, YTHDF1, YTHDF2, HNNRPC, LPPPRC, RBMX, FTO and ALKBH5, were significantly overexpressed in COPD patients. The gene discussed is YTHDC2; the disease is chronic obstructive pulmonary disease.