Using an RF model, SVM model and nomogram, the study identified 11 m6A methylation regulators (LRPPRC, YTHDC1, YTHDF1, HNRNPA2B1, WTAP, CBLL1, RBM15, HNRNPC, YTHDF2, RNMX and FTO) that could predict the occurrence of COPD effectively. This evidence concerns the gene HNRNPA2B1 and chronic obstructive pulmonary disease.