We detect significant upregulation of Oct1 and Oct2, members of the POU II class, at the protein level and Oct2 mRNA, in miR196b–/–Dnmt3a+/–Flt3ITD as compared to Dnmt3a+/–Flt3ITD AML cells (Fig. 2C, D and Supplementary Fig. 2B) and miR-196b–/– versus wild-type bone marrow (Fig. 2C). Here, POU2F1 is linked to acute myeloid leukemia.