Intersection of genes upregulated in miR196b–/–Dnmt3a+/–Flt3ITD AML by RNA-seq with miR-196b predicted targets and previously published experimentally defined miR-196b targets in MLL-rearranged AML [9] further support Oct1 as a potential target of miR-196b (Supplementary Fig. 2D). This evidence concerns the gene KMT2A and acute myeloid leukemia.