To understand the mechanism(s) of accelerated leukemogenesis in miR196b–/–Dnmt3a+/–Flt3ITD mice, we performed RNA-seq on c-Kit+ AML cells isolated from moribund miR196b-/-Dnmt3a+/-Flt3ITD and Dnmt3a+/-Flt3ITD mice as controls. This evidence concerns the gene DNMT3A and acute myeloid leukemia.