Conversely, 14 genes were significantly down-regulated, including AHNAK, LRP1, CDKL5, and HIST1H3J. Altogether, the combined transcriptome analysis hinted towards strikingly subtle differences between CT and non-CT tumours, given the substantial difference in aggressiveness of CT as compared to non-CT medulloblastomas. The gene discussed is LRP1; the disease is medulloblastoma.