TP53 and neoplasm: We performed single-cell DNA and RNA-seq (single-cell and single-nuclei sequencing; hereafter termed single-cell (sc) seq) of paediatric medulloblastomas with CT that carry a germline TP53 variant (LFS, n = 7, including 3 patient tumours and 4 patient-derived xenograft (PDX) models, primary and relapsed, see Fig. 1 & Supplementary Data 1).