The downregulated differentially expressed genes (DEGs) were enriched in KEGG pathways related to ribosome biogenesis (RPL11, RPL14, RPS6, RPL12, RPL21, RPL13, RPS15, RPS9, RPL3, RPS4X etc.)(Fig. S4E), and Maturity Onset of Diabetes in the Young (MODY) (NR5A, NKX6.1, GCK, INS, IAPP, ONECUT1, FOXAA3, FOXA2, HNF4A, etc.)(Fig. S4F). This evidence concerns the gene ONECUT1 and diabetes mellitus.