The downregulated differentially expressed genes (DEGs) were enriched in KEGG pathways related to ribosome biogenesis (RPL11, RPL14, RPS6, RPL12, RPL21, RPL13, RPS15, RPS9, RPL3, RPS4X etc.)(Fig. S4E), and Maturity Onset of Diabetes in the Young (MODY) (NR5A, NKX6.1, GCK, INS, IAPP, ONECUT1, FOXAA3, FOXA2, HNF4A, etc.)(Fig. S4F). The gene discussed is GCK; the disease is diabetes mellitus.