After the discovery of the MACC1 gene, it has been proven various times that the gene-specific targeting of MACC1 expression using small interfering RNA (siRNA), short hairpin RNA (shRNA) or micro RNA (miRNA) leads to reduced migratory properties and cellular invasion, while this simultaneously induces apoptosis, elevates chemo-sensitivity of cancer cells and ultimately also inhibits metastasis formation in vivo [5]. Here, MACC1 is linked to cancer.