This was further corroborated in pancreatic cancer, where the c-MET inhibitor JNJ-38877605 did not prevent direct protein–protein interaction of MACC1 with the EMT-marker SNAI1, resulting in the upregulation of fibronectin 1 (FN1) and a repression of E-cadherin [11]. Here, MET is linked to familial pancreatic carcinoma.