MACC1 and head and neck cancer: Moreover, MACC1 has also been established as a negative prognostic marker in genitourinary (kidney, bladder, ovarian, cervical and endometrial cancer), skin, breast, lung, head and neck cancer (head and neck, tongue, nasopharynx, salivary gland) as well as glioblastoma and retinoblastoma [17–29].