Furthermore, Wnt/β-catenin can affect the secretion of cytokines such as chemokine (C–C motif) ligand (CCL)4 and CCL5, reducing dendritic cell recruitment, while the secretion of Wnt-induced secreted protein 1 (WISP-1) promotes TAM and a pro-tumor TME [152, 160]. Here, CCN4 is linked to neoplasm.