MACC1 and retinoblastoma: In addition, CD133low retinoblastoma (Y79) stem cells showed a higher expression of several embryonic stem cell genes (HOXB2, HOXA9, SALL1, NANOG, Oct4, LEFTY), stem cells/progenitor genes (MSI2, BMI1, PROX1, ABCB1, ABCB5, ABCG2), and the metastasis related gene MACC1, when compared to CD133high cells [146].