These factors include a positive feedback loop of MACC1 towards c-MET, the stimulation of VEGF secretion, desensitization towards induced cell-death, induction of cancer cell stemness, alteration of cellular energetics, and the stimulation of multiple signaling cascades such as STAT, Wnt/β-catenin, and PI3K/AKT [149]. This evidence concerns the gene MACC1 and cancer.