MACC1 and neoplasm: It was demonstrated that in esophageal squamous cell carcinoma (SCC) MACC1 expression correlated positively with the expression of Snail, which has been associated with tumor epithelial-mesenchymal transition (EMT) and less favorable, more advanced tumor stages, lymph node metastasis (LNM) and Tumor Nodes Metastasis (TNM) stages [16].