BLM-induced expression of AKT1 and NLRP3 in the mouse lung tissue was decreased in the DsbA-L-KO + Model group compared with the WT + Model group (Fig. 6A), indicating that DsbA-L positively regulated the abundance of AKT1 and NLRP3 in vivo, which was consistent with the cellular experiments. This evidence concerns the gene NLRP3 and Bloom syndrome.