CDK4 and mantle cell lymphoma: For instance, ARV-825 and ARV-771 significantly inhibited cell proliferation and promoted cell apoptosis [73, 75, 110, 111], moreover, they strongly downregulated the expression of MYC in DLBCL and BL [75, 110, 111], and the expressions of CDK4/6 and cyclin D1 in MCL [73].